Additionally, a significant improved in the ratio of F0-1 hepatic fibrosis degree, TG, HDL-C and LDL-C were noted in the 5:2 IF diet group after 12-week treatment (p < 0.05), however, lower FBS, fasting insulin and hs-CRP were noted in the daily calorie restriction eating group (p < 0.05). Here, INS is linked to Hepatic fibrosis.