AKT1 and cancer: Andrographolide has been observed to regulate various signaling pathways associated with cancer and angiogenesis, including PI3K/AKT/mTOR (21, 22), SRC/MAPKs/AP-1 (23), TLR4/NF-κB/MMP-9 (24), and VEGF/VEGFR2/AKT (25).