Our results also showed that the association between APOE-ɛ4 genetic status and rate of atrophy in the hippocampus and the Alzheimer's disease-vulnerable regions increases with advancing age (Fig. 2C and D), in line with the age-related increase in Alzheimer's disease pathology accumulation98 and the age-related increase in Alzheimer's disease-related cognitive impairment. This evidence concerns the gene APOE and Cognitive impairment.