To address these gaps, the current study examined rates of change in regional brain volumes and WMH in a large, harmonized dataset of middle-aged and older individuals with normal cognition at baseline (mean MRI follow-up = 5.3 years, max = 24 years), with both APOE genotypes (N = 1541) and AD-PRS scores (N = 1093) available. Here, APOE is linked to Alzheimer disease.