NLRP3 and early-onset autosomal dominant Alzheimer disease: Furthermore, a recent epidemiological study reported that long-term use of diclofenac, a non-steroidal anti-inflammatory drug which inhibits NLRP3 and is often prescribed for the treatment of conditions such as arthritis, is associated with reduced incidence of Alzheimer’s disease and slower cognitive decline.32 NLRP3 inhibiting drugs are therefore currently being investigated as a potential therapeutic strategy in Alzheimer’s disease.