NLRP3 and early-onset autosomal dominant Alzheimer disease: Recent work links the NLRP3 inflammasome to several neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease and ALS caused by SOD1 mutations27-30 Genetic or pharmacological inhibition of NLRP3 rescues cognitive impairments in different rodent models of Alzheimer’s disease,26,31 suggesting that the inflammasome can directly contribute to disease pathogenesis in dementia.