MAX and neoplasm: Instead, cluster 2 tumors include neoplasms due to mutations of the neurofibromatosis type 1 (NF1) tumor suppressor gene, the rearranged during transfection (RET) proto-oncogene, genes encoding transmembrane protein 127 (TMEM127), MYC-associated factor X (MAX) and HRAS. Mutations of cluster 2 genes regard activation of kinase receptor signaling pathways, translation initiation, protein synthesis, and pathways involved in maintenance of neural/neuroendocrine identity (26).