TNFRSF1A and diabetic kidney disease: Tumor necrosis factor receptor-1 (TNFR-1) and tumor necrosis factor receptor-2 (TNFR-2) are linked to immune regulation and tissue regeneration, showing a higher specificity for tumor necrosis factor (TNF-α), which are key mediators in the inflammatory response seen in DKD (17, 18).