In our previous report, we showed treatment with an AhR ligand, indole-3-carbinol (I3C), reduced disease severity and disease-associated intestinal microbial dysbiosis in murine models of colitis, which appeared dependent on IL-22 production by innate lymphoid type 3 cells (ILC3), not T helper 22 (Th22) cells (37). Here, IL22 is linked to colitis.