Hepatocyte nuclear factor 3γ (HNF3γ) is a hepatocyte nuclear factor that can inhibit HCC growth by transactivating organic anion transporting polypeptide 1B1 (OATP1B1) and 1B3 (OATP1B3) expression, which sensitizes HCC cells to sorafenib-induced growth inhibition and apoptosis (40). This evidence concerns the gene SLCO1B3 and hepatocellular carcinoma.