ACLY and hepatocellular carcinoma: Another study showed that high levels of METTL3/14 enhanced the expression of ATP citrate lyase (ACLY) and stearoyl-CoA desaturase 1 (SCD1) by regulating their mRNA stability, which accelerated fatty acid synthesis and lipogenesis, ultimately leading to lipid peroxidation or endoplasmic reticulum stress, resulting in HCC cell death and a decrease in HCC cell viability (42).