The upregulated expression of METTL3 caused by HBx (an X protein encoded by hepatitis B virus) increases the m6A modification level of circ-ARL3 and then leads to increased stability and enhanced expression of circ-ARL3, causing dysregulation of the circ-ARL3/miR-1305 axis and ultimately facilitating HCC progression (28). This evidence concerns the gene METTL3 and hepatocellular carcinoma.