By modifying the methylation of circular RNA (circRNA) (28, 66), long noncoding RNA (lncRNA) (29–32), and transcripts of other cancer-associated genes (33–37), METTL3 is involved in the progression of HCC by regulating the stability of related RNAs (Figure 3, Table 1). This evidence concerns the gene METTL3 and hepatocellular carcinoma.