SLCO1B3 and hepatocellular carcinoma: THNF3γ reduction caused by METTL14 knockdown upregulates the expression of the sorafenib influx transporters OATP1B1 and OATP1B3, thereby rendering sorafenib resistance in HCC, and enforced HNF3γ expression enhances the cellular response to sorafenib in HCC (40).