Additionally, IGF2BP1 enhances alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V (MGAT5) mRNA stability by increasing m6A modification, which contributes to the promotion of the HCC stem cell phenotype, self-renewal, chemotherapy resistance, and tumorigenesis in mice (59). Here, IGF2BP1 is linked to hepatocellular carcinoma.