CCL2 and cryptococcosis: Another study in rats showed that lung macrophages, after C. neoformans phagocytosing, induce the synthesis of monocyte chemotactic protein 1 (MCP-1), depending on the interaction of C. neoformans with CD11b/c and CD18 and, interestingly, aging appears to be related to a reduced production of MCP-1 by lung macrophages in response to cryptococcal infection (141).