Indeed, beyond CTLA-4 and PD-1, other immune check point molecules such as NKG2A, TIM (T cell immunoglobulin domain and mucin domain)-3, LAG (lymphocyte activation gene)-3, and TIGIT (T-cell immune-receptor with Ig and ITIM domains), which are expressed in CD8 and natural killer (NK) cells can also be referred to tumor resistance to immune cells (1, 2). The gene discussed is KLRC1; the disease is neoplasm.