Finally, SAG-treated embryos also displayed adownregulation of transcripts associated with neuronal function, including genesassociated with neurodevelopmental disorders (Irf2bpl) (Marcogliese et al., 2018), epilepsy and autism spectrum disorders(Cntnap2) (Peñagarikano et al.,2011), epilepsy and ataxia (Kcna1) (Smart et al., 1998), and GABAergic neuron development andfunction (Tal2) (Bucher et al.,2000; Achim et al., 2013). This evidence concerns the gene SAG and neurodevelopmental disorder.