Cox regression analysis showed that a total of 15 upregulated proteins—BSG, HSP90AB1, SLC44A1, GP9, CHCHD3, GSR, SLC16A1, CALR, SF3A2, IGSF9, IMPDH2, EMLIN1, PARVB, CA, and CHLI—and 15 downregulated proteins—ARNT, ATP6V0A1, PLEKHO2, PNPLAB, CFP, WIPF1, ANGPTL6, SDCBP, ITGAL, CD5, MFGE8, CD37, PTRF, F5 and SELL—were independently associated with the survival of NB patients (Figure 2A). The gene discussed is IGSF9; the disease is neuroblastoma.