HLA-C and neoplasm: Moreover, once the adrenal gland has been infiltrated, corticosteroids produced there may play a key role in helping the tumour cells evade immune response; glucocorticoids have a well-described immunosuppressive effect wherein they impede lymphocyte proliferation and function, limit the activity of major histocompatibility complex (MHC) class I and II, decrease the ability of T cells to recognize tumour cells, and even upregulate the protein β-catenin which contributes to immune cell exclusion in the tumour’s microenvironment (8).