With respect to the type of dementia, rs11062164 of CACNA1C, rs16916777 of GABBR2, and rs17738042 of SH3PXD2A are associated with vascular dementia; rs10184275 and rs2119067 of SCN2A are associated with late-onset Alzheimer’s disease; and, rs12592898 of CTSH and rs4607615 of MSRA are associated with Alzheimer’s disease. The gene discussed is SH3PXD2A; the disease is early-onset autosomal dominant Alzheimer disease.