ACE2 and infection: This is important not only because the ACE2 protein receptor is involved in the development of infections, but also because it is suggested to be a potential target for therapy.6 The ACE2 gene is located on chromosome Xp22; a functional single nucleotide polymorphism (SNP) in the ACE2 gene ‘G8790A (rs2285666)’ in intron 3 could alter mRNA splicing and so affect ACE2 gene expression.7 In addition, rs2285666 is suggested to alter the binding affinity of the ACE2 protein receptor for SARS-CoV-2.8