ACE2 and COVID-19: Also, TMPRSS2 gene polymorphisms have been associated with susceptibility to COVID-19 infection and outcome.32 In a study on Italian patients in 2020, Asselta et al. revealed that TMPRSS2 SNPs-rs2070788, rs9974589, and rs7364083 were associated with increased severity of COVID-19.32 Moreover, Fuentes et al. reported that rs61735794 and rs61735792 were significantly associated with COVID-19 infection outcome.33 In this work, no significant associations were detected between either the ACE2 rs2285666 SNP or the TMPRSS2 rs2070788 SNP and COVID-19 severity and outcome.