The co-regulatory analysis suggests the formation of protein integration complexes between overregulated TFs (CAMTA1, CBFB, CEBPB, ETV4, FOXM1, HES6, JUN, MYC, NFE2L3, PHF19, SOX4, SOX9, and TEAD4) controls transcriptional regulatory function during the acquisition of the hallmarks of cancer. The gene discussed is CBFB; the disease is cancer.