RAB31 and gastric cancer: RAB31 is a common overregulated gene in gastric cancer and it might be able to distinguish the intracellular vacuole of human-adapted and broad-host SEST, which may have implications for the understanding of the marked differences between SEST’s biology and the fine-tuning of T3SSs activity to adapt their function to the unique requirements of each SEST because differences in a single type III secretion effector protein result in fundamental changes to Salmonella’s intracellular niche (Spanò et al., 2011).