The EBV-encoded LMP1 oncogene is involved in the transformation, proliferation, and metastasis of several EBV-associated tumors, which are related to its ability to upregulate anti-apoptotic proteins and growth signals and the expression of p38 (MAPK13) in response to stimuli such as stress or primary infection that lead to an increase in LMP1 promoter activity, and may allow the cells to escape apoptosis, suggesting the presence of a positive autoregulatory loop in LMP1 upregulation (Johansson et al., 2010). The gene discussed is PDLIM7; the disease is infection.