CDH1 and neoplasm: TCF3 (E2A immunoglobulin enhancer-binding factors E12/E47) E12 forms heterodimers with other basic helix-loop-helix proteins during cell differentiation, whereas E47 can homo and heterodimerize, promoting tumor angiogenesis and proliferation (Peinado et al., 2004); both act as transcriptional repressors of E-cadherin during EMT, which is linked to tumor aggressiveness (Perez-Moreno et al., 2001).