Furthermore, E6 can selectively upregulate WNT4, JIP1, and JIP2 translation, resulting in the activation of the non-canonical WNT-PCP-JNK pathway through the phosphorylation of mitogen-activated protein kinase (Figure 7) to promote cell proliferation and tumor growth (Zhao et al., 2019). This evidence concerns the gene MAPK8IP1 and neoplasm.