SOX4 overexpression promotes sphere formation and the self-renewal of colorectal cancer cells (Figure 2), which directly bind to the HDAC1 promoter, encouraging HDAC1 transcription and thereby stem cell maintenance, Wnt, Notch, the cell cycle, and transcriptional misregulation pathways in cancer (Liu et al., 2021b). The gene discussed is HDAC1; the disease is colorectal cancer.