NETO2 (Neuropilin and tolloid-like 2) is a common overexpressed gene in lung cancer that encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A domain (Figure 6), which may also be related to HTLV-1 infection, as it has been associated with clinical stage and lymph node metastasis, cell proliferation, apoptosis, tumor growth, migration, and EMT, increasing the phosphorylation of ERK (Xu et al., 2021a). The gene discussed is EPHB2; the disease is lung carcinoma.