E7 oncoprotein rapidly induces centrosome abnormalities thereby causing the formation of supernumerary mitotic spindle poles and increasing the risk of chromosome mis-segregation (Figure 6) through a process that involves an increase in PLK4 mRNA steady-state levels (Korzeniewski et al., 2011) and tubulin gamma 1 (Starita et al., 2004), which are both overregulated common genes in lung cancer (Supplementary Table 1). Here, PLK4 is linked to lung carcinoma.