SOX4 is overregulated in all ten lung cancer datasets and is related to: 1) apoptosis along with E2F1; 2) cell proliferation along with FOXM1, DLX5, and E2F3; 3) the formation of TF complexes along with E2F3, ARNTL2, HMGA1, HOXA10, and TCF3; 4) the positive regulation of transcription along with E2F1, FOXM1, ETV4, DLX5, FOXE1, HMGA1, and TCF3; and 5) the positive regulation of the Wnt signaling pathway along with DLX5 (Supplementary Table 1). The gene discussed is HMGA1; the disease is lung cancer.