EPHB2 and neoplasm: NETO2 (Neuropilin and tolloid-like 2) is a common overexpressed gene in lung cancer that encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A domain (Figure 6), which may also be related to HTLV-1 infection, as it has been associated with clinical stage and lymph node metastasis, cell proliferation, apoptosis, tumor growth, migration, and EMT, increasing the phosphorylation of ERK (Xu et al., 2021a).