Junction plakoglobin (JUP), also known as γ-catenin, a major component of the submembrane of adherens junctions and desmosomes in mammalian cells, can interact with cadherin 3 in adherens junctions in the cytoplasmic component; both are common overregulated genes in lung cancer (Supplementary Table 1) and bind to SOX4 via two trypsinized fragments (Figure 6), while Wnt signaling induces the nuclear colocalization of SOX4 and JUP (Lai et al., 2011). This evidence concerns the gene SOX4 and lung cancer.