In colon cancer, adaptor related protein complex 1 subunit mu 1 (AP1M1), subunit sigma 2 (AP1S2), and subunit sigma 3 (AP1S3) are common overregulated genes and might be related to the accumulation of IFITM3 protein on the cell surface (Figure 7). Here, AP1S3 is linked to malignant colon neoplasm.