The key virulence factor in live EHT may also elicit the fast release of mucin by goblet cells as EhCP5 couples with goblet cell αvβ3 receptors and degrades the colonic mucus layer at the site of invasion (Cornick et al., 2016), suggesting that ITGA5, ITGB5, and integrin subunit beta like 1 (ITGBL1) might be related to amoebiasis infection in gastric cancer. Here, ITGB5 is linked to gastric cancer.