ITGB4 and urokinase-type plasminogen activator (uPA) encoded by PLAU, two common overregulated genes in lung cancer, promote angiogenesis via ERK1/2 phosphorylation, leading to cell growth (LaRusch et al., 2010; Breuss and Uhrin, 2012). The gene discussed is ITGB4; the disease is lung carcinoma.