Non-canonical WNT signaling could be related to TCF3 upregulation in colon cancer (Figure 4), along with other key overregulated TFs, and the formation of transcriptional regulatory complexes according to DAVID ́s analysis (Supplementary Table 2); therefore, it might be involved in the control of gene expression for the acquisition of the hallmarks of cancer (Figure 1). The gene discussed is TCF3; the disease is malignant colon neoplasm.