All our findings must be experimentally validated with proper methodologies to specifically prove how, when, and where: 1) the microbiome network is interacting with the membrane receptors of cancer-related cells; 2) the host-microbiome interaction activates the signaling pathways related to gene expression; and 3) the cancer TRN is regulating the crosstalk with the microbiome network. The gene discussed is TNPO1; the disease is cancer.