TNF and cancer: There is evidence that suggests an important role of TEAD4, ETV4, and PRRX1 regulatory activity, the main TFs identified in the TRN analysis (Figure 2), during the TNF and IFN singling pathway in gastric tumorigenesis (Figure 8), along with STAT1 and CEBPB, that might be validated experimentally, to establish their importance during the acquisition of the hallmarks of cancer.