EBV is a ubiquitous gamma herpesvirus that causes persistent infections and some lymphoid and epithelial tumors (Osorio et al., 2022a) and might use G protein-coupled receptor (GPCR) signaling (Zhang et al., 2016), like GPR87, a common overregulated DEG in lung cancer (Figure 6). This evidence concerns the gene EDNRA and lung carcinoma.