EBV Bam HI fragment H rightward open reading frame (BHRF1) is a viral homolog of cellular BCL-2 pro-survival proteins (vBCL-2s) and confers strong resistance to diverse apoptotic stimuli and interacts with the cellular pro-apoptotic BCL-2 protein BID in colon cancer (Figure 7) to inhibit DNA-damage-induced apoptosis (Fitzsimmons et al., 2020). Here, BID is linked to malignant colon neoplasm.