The co-regulatory analysis suggests the formation of protein integration complexes between overregulated TFs (CAMTA1, CBFB, CEBPB, ETV4, FOXM1, HES6, JUN, MYC, NFE2L3, PHF19, SOX4, SOX9, and TEAD4) controls transcriptional regulatory function during the acquisition of the hallmarks of cancer. This evidence concerns the gene NFE2L3 and cancer.