In lung cancer, ITGB4 might be related to leucine-rich repeat-containing protein 15 (LRRC15), which is involved in cell-cell and cell-matrix interactions and overexpressed in mesenchymal-derived tumors (Ray et al., 2022), exerting a metastatic invasion role in lung cancer (Ruan et al., 2022). This evidence concerns the gene LRRC15 and lung cancer.