Increased CHK1/2 activity by Tax during S phase restricts the CDK-dependent phosphorylation of FOXM1, preventing the premature expression of G2/M genes, including those encoding cyclin-dependent kinase 4, cyclin B1, and cyclin A2 (Branigan et al., 2021), all common DEGs in lung cancer (Supplementary Table 1). The gene discussed is CDK4; the disease is lung cancer.