Colon cancer common overregulated DEGs are related to epigenetics reprogramming (phosphorylation, acetylation, methylation, and ubl conjugation), the formation of extracellular exosomes, cell adhesion, proliferation, apoptosis, junctions, migration, and division, the regulation of transcription, DNA damage, repair, and replication, the formation of TF complexes, and stem cell proliferation, as well as signaling involved in the cell cycle, proteoglycans in cancer, cellular senescence, amoebiasis, malaria, and hepatitis C virus (HCV), EBV, HPV, and HTLV-I infection (Supplementary Table 2). This evidence concerns the gene TF and cancer.