The global transcriptomic network analysis of gut and lung cancer highlights the impact of five TFs (SOX4, TCF3, TEAD4, ETV4, and FOXM1) that might be related to stem cell programing and cancer progression through the regulation of the expression of an important number of common deregulated genes, such as cancer-cell membrane receptors that interact with several microorganisms, including HTLV-1, HPV, EBV, and SARS−CoV−2. The gene discussed is TCF3; the disease is cancer.