WNK2 and malignant colon neoplasm: The non-canonical Wnt signaling pathway might be involved in colon cancer progression (Figure 7), specifically in planar cell polarity (PCP), in which WNT2 binds to FZD3, a frizzled transmembrane receptor, to activate ankyrin repeat domain 16 (ANKRD16), ras homolog gene family members B and Q (RHOB and RHOQ), and a mitogen-activated protein kinase, MAP3K20, modifying JUN phosphorylation and its transcriptional regulatory function, which affects cell polarity and cytoskeleton organization (Gómez-Orte et al., 2013).