According to the TRN of lung cancer (Figure 3), SOX4, FOXM1, ETV4, HOXC6, and E2F3 are the main positive regulators, whereas SOX17, KLF4, and ZBTB16 are the main negative regulators of transcription, controlling the expression of other TFs and target genes in lung cancer. Here, KLF4 is linked to lung cancer.