In colon cancer, WNT2 might bind to FZD3 to upregulate AXIN2, as well as RNF43 for its negative feedback regulation (Jho et al., 2002), in which the modification and degradation of β-catenin are key pathway events in tumor progression (Zhao et al., 2022). The gene discussed is RNF43; the disease is malignant colon neoplasm.