The interaction between SDC1 and HMMR, the hyaluronan-mediated motility receptor overregulated in lung cancer, is related to tumor cell motility and differentiation (Yeh et al., 2018), as well as the pathological stage, T classification, lymph node metastasis, and distant metastasis (Li et al., 2021). The gene discussed is HMMR; the disease is lung cancer.