BTG3 and systemic lupus erythematosus: An “abnormal titer” of ANA assessed by immunofluorescence (IF) microscopy (IF-ANA) is one of the 11 classification criteria for SLE according to the 1982 American College of Rheumatology (ACR-82) whereas the 2012 Systemic Lupus International Collaborating Clinics (SLICC-12) criteria state that an ANA test “above the laboratory reference value” remains a criterion for SLE (7, 8).