These results indicated that gap junction regulation could improve arrhythmia caused by C. sakazakii and sepsis, which was consistent with recent study that decreased Panx1 by CBX inhibited inflammatory cytokines and apoptosis via inhibiting NLRP3 inflammasome activation and regulating apoptotic protein Bax and Bcl2 levels, respectively.16 The gene discussed is BCL2; the disease is Sepsis.