SIRT2 and deep vein thrombosis: However, the increase of PC(17:0/20:4) and PC(18:0/20:4) will lead to the decrease of SIRT2 level, and the increase of PC(18:0/20:5) will lead to the decrease of CCL20 level (0 < OR < 1), and the decrease of SIRT2 and CCL20 levels will lead to the decrease of DVT risk.