INS and hypertensive disorder: Indeed, increased levels of bioavailable testosterone (7) and declining estrogen levels (11) could lead to increased risk factors, such as a change in the composition and distribution of abdominal visceral fat or lipid deposition around the heart and aorta (12), altered insulin action [in terms of insulin sensitivity and glucose tolerance; (13, 14)], and hypertension (15), all of which are related to increased cardiovascular morbidity (16).