SCN1A and Seizure: A study on Hong Kong Chinese patients investigated 27 SNPs in SCN1A, SCN2A, and SCN3A genes, and found that SCN2A rs2304016 was associated with both DRE, defined as one or more seizures per month for 1 year under ASM treatment, and resistance to SCN blockers, defined as patients with DRE when their most recent ASM regimen consisted of SCN-blocking ASMs (Kwan et al., 2008).