TNFSF18 and myocardial ischemia: Similarly, the activation of the tumor necrosis factor(ligand) superfamily, member 18 (TNFSF18) inflammasome incoronary endothelial cells has been demonstrated to induce adhesion moleculeexpression, further perturbing coronary microcirculation in atherosclerosis [36].Persistent activation of these inflammatory cascades can lead to microvascularremodeling, characterized by intimal thickening and luminal narrowing, whichimpairs coronary blood flow and can manifest as myocardial ischemia or infarction[37].