Then, the results of the EPIC-Norfolk study [13], which investigated theassociation between Lp(a) levels and long-term CAD, IS, and calcific aortic valve stenosis (CAVS) in apopulation-based study of 25,663 men and women aged between 45 and 79 yearsresiding in Norfolk (UK), demonstrated a link between high Lp(a) with prevalentCAD and CAVS in both men and women but not with ischemic stroke in women. This evidence concerns the gene LPA and ischemic stroke.