HMGCR and Alzheimer disease: Notably, HMGCR inhibition exhibited arobust protective effect against TAA (odds ratio (OR): 0.556, 95% CI:0.372–0.831, p = 0.004), AAA (OR: 0.202, 95% CI: 0.107–0.315,p = 4.84 × 10-15), and AD (OR: 0.217, 95% CI:0.098–0.480, p = 0.0002).