Sodium–glucose cotransporter 2 (SGLT2), predominantly expressed in the proximalrenal tubules, plays a pivotal role in glucose transport across the epithelium.Emerging evidence suggests that it is upregulated in cardiomyocytes of patientssuffering from heart failure [21], and its potential proinflammatory activity mayimpact cardiovascular function through excessive inflammation [22, 23]. This evidence concerns the gene SLC5A2 and heart failure.