In mice with type 2 diabetes,aerobic exercise has been found to inhibit P2X purinoceptor 7 (P2X7) purinergic receptors, resultingin reduced Caspase-3 levels, a decreased Bcl2 associated X protein (Bax)/B-cell lymphoma/leukemia 2 (Bcl2) ratio, and suppressedmyocardial apoptosis, leading to improved cardiac remodeling and relieved cardiacdysfunction [22]. The gene discussed is P2RX7; the disease is type 2 diabetes mellitus.