Additionally,another study demonstrated that early moderate-intensity aerobic exercise reducedthe expression of IkappaBalpha (IκBα), nuclear factor-kappa B (NF-κB), cyclooxygenase-2 (COX-2), and IL-8,leading to decreased inflammatory responses, improved myocardial remodeling, andenhanced cardiac function in doxorubicin-induced HF [31]. This evidence concerns the gene PTGS2 and hydrops fetalis.