NOX1 and endothelial dysfunction: It was shown that not “oxidized”(lipoperoxide-containing) LDL, but dicarbonyl-modified LDL are atherogenic(actively captured by cultured macrophages with the help of scavenger receptors),and also cause expression of lectin like oxidized low density lipoproteinreceptor 1 (LOX-1) and nicotinamide adenine dinucleotide phosphate(NADPH) oxidase 1 (NOX-1) genes in endotheliocytes, which stimulateapoptosis and endothelial dysfunction.