Despite theseprocesses, the expression of genes relating to the key factors of apoptosis(BCL2-associated X protein (BAX), caspase 9, and caspase 3)elevates, which finally stimulates damage and apoptosis in endotheliocytes [53].Thus, the initial stages in the development of endothelial dysfunction known toplay the leading role in atherogenesis and diabetogenesis directly depend on theformation of non-oxidized (LOOH-containing) but dicarbonyl-modified LDL [53]. This evidence concerns the gene BAX and endothelial dysfunction.