Several key signaling kinases, including extracellular signal-regulated protein kinases (ERK) one and 2, ataxia-telangiectasia mutated (ATM) kinase, JNK1, CDK2, PI3K, and Rad 3-related kinase, phosphorylate Sp1 to control proliferation, movement, and invasion of tumor cell. Here, MAPK8 is linked to neoplasm.