Moreover, arginine is able to enhance Sp1 stability without relying on ERK, resulting in the creation of the “Sp1 stability cycle.” Therefore, the increase in SIRPA expression enhances the spread of osteosarcoma by activating the “Sp1 stable cycle” and facilitating arginine absorption through SLC7A3, making it a promising target for osteosarcoma treatment. This evidence concerns the gene SP1 and osteosarcoma.