Briefly, in BRAFV600E-induced cancer cells, the GABP tetramer facilitates the activation of ERK-recruited mutated TERT promoters; ERK activation promotes the dissociation of HDAC1 from Sp1/HDAC1 complex by upregulating the phosphorylation levels at sites, such as Sp1 Thr 739. The gene discussed is SP1; the disease is cancer.