For example, Sp1 can maintain the continuous tumor proliferation signal by mediating the transcription of epidermal growth factor (Pascall and Brown, 1997) and its receptor (Kageyama et al., 1988; Kitadai et al., 1992), fibroblast growth factor (Payson et al., 1998; Jimenez et al., 2004), insulin-like growth factor (Hyun et al., 1993; Jiang et al., 2004), and its receptor (Jensen et al., 1995; Ohlsson et al., 1998; Abramovitch et al., 2003; Maor et al., 2007). This evidence concerns the gene SP1 and neoplasm.