SP1 and cancer: Mir et al. (2018) demonstrated that GSK3β can promote Sp1 phosphorylation at S726 and S732 sites in colorectal cancer cell lines lacking Wnt signaling. Additionally, it induces the degradation of phosphorylated Sp1 by β-TrCP-mediated ubiquitination. Therefore, the synergistic effect of Sp1 phosphorylation and ubiquitination mediates its degradation, which has the eventuality of transformation to promote innovativeproposals for treatment and safeguard against cancer.