Sp1 activates the angiogenic pathway through regulating the vascular endothelial growth factor (Abdelrahim et al., 2004; Stoner et al., 2004; Yao et al., 2004; Abdelrahim and Safe, 2005; Yu et al., 2010; Eisermann et al., 2013), platelet reactive protein 1 (Okamoto et al., 2002), platelet-derived growth factor (Santiago and Khachigian, 2004), urokinase plasminogen activator (Trisciuoglio et al., 2004; Belaguli et al., 2010), and anti-angiogenic genes to meet the nutritional and oxygen requirements of tumor growth. The gene discussed is SP1; the disease is neoplasm.