CD44 and breast carcinoma: Zhang et al. (2006) reported that trichostatin A (TSA) promotes LH receptor (LHR) gene level in human breast cancer cells (MCF-7) and human placental villous cells (JAR) by enhancing PI3K/PKC phosphorylation at Ser641, which finally promotes the release of suppressor protein p107 from the LHR promoter gene.