Indeed, specific mutations in TDP2 have been linked to the human genetic disorder Spinocerebellar ataxia autosomal recessive 23 (SCAR23), which is characterized by intellectual disability, seizures, and ataxia (Zagnoli-Vieira et al., 2018; Errichiello et al., 2020). This evidence concerns the gene TDP2 and spinocerebellar ataxia, autosomal recessive 23.