Interestingly, a mouse brain tumor model studying ZFTA-RELA fusion found that the ZFTA-RELA fusion protein product contains a C2H2 zinc finger domain similar to PLAGL1, and binds to genome sites enriched with PLAGL family transcription factor motifs [2], potentially recognizing a similarity in mechanistic transcriptional regulation between ZFTA-RELA fusion ependymomas and ependymal-like tumors with PLAGL1 rearrangement. This evidence concerns the gene PLAGL1 and ependymoma.