Similar findings including EVs containing hypoxia-inducible factor (HIF) -1α can promote angiogenesis through the PI3K/Akt/mTOR pathway [81], and another EV-derived protein Rab13 can promote angiogenesis by upregulating VEGF in HCC cells [82], further demonstrated the positive effects of EV-associated proteins on angiogenesis. This evidence concerns the gene VEGFA and hepatocellular carcinoma.