One kind of EV-derived protein, von Willibrand factor (vWF) can upregulate the levels of VEGF-A and fibroblast growth factor 2 (FGF2) in endothelial cells to promote angiogenesis, and FGF2 can promote HCC cell growth in a positive feedback manner by activating the FGFR4/ERK1 signaling pathway [80]. This evidence concerns the gene FGF2 and hepatocellular carcinoma.