Although there were only three patients with GDM and no hypertension case in our study, Coprococcus positively links to Perio-associated triglyceride, CRP, and fasting blood glucose, echoing that Coprococcus member links to serum metabolic and corpulence traits as well as clinical comorbidities [38, 39], possibly due to fructose-induced obesity [40]. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.