The most interesting finding in this study was that serum CES1 levels were significantly associated with lipid metabolism (ALT, AST, TG, TC, LDL-C), glucose metabolism (FBI, HOMA-IR) and obesity-related secreted proteins (adiponectin, leptin, GDF15, IGF-1). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.