Considering the dual effects of MALT1 in immune TIME and cancer cells, that is, inhibiting MALT1 protein activity affects tumor cell proliferation, survival, and invasion while reprogramming activates Tregs to secrete IFNγ, the use of MALT1 inhibitors could appropriately multiply the anti-tumor immunity, improve ICT response in solid cancers, and reduce tumor cell growth and infiltration with less effort. The gene discussed is MALT1; the disease is neoplasm.