In addition, HE and immunohistochemical staining revealed that POSTN knockdown reduced the number of Treg cells, as indicated by the presence of FOXP3, increased the number of CD8+ T cells, increased the number of apoptotic cells (as indicated by the presence of cleaved caspase-3) and reduced tumor growth (Fig. 8E). This evidence concerns the gene FOXP3 and neoplasm.