To further explore the role of microglia with immunophenotypic regulation by the POSTN protein in the immune microenvironment of GBM, we identified the 30 genes with the greatest changes in expression, as determined by RNA-seq analysis of HMC3 cells, and found that the expression levels of 4 of these genes were related to those of POSTN in the TCGA database (Fig. 5D and E, Supplementary Table S3). This evidence concerns the gene POSTN and glioblastoma.