Figure 4 shows that the number of cells positive for BrdU, P-NCAM and BrdU/P-NCAM in the hippocampal niche of AD-GFP mice is lower compared with WT-GFP mice but it is partially recovered in AD-Nup153-GFP mice (P-NCAM+: WT-GFP 3268 ± 215, AD-GFP 428 ± 22, AD-Nup153-GFP 1512 ± 37; BrdU+: WT-GFP 1572 ± 220, AD-GFP 246 ± 9, AD-Nup153-GFP 1093 ± 30; BrdU+/P-NCAM+: WT-GFP 761 ± 82, AD-GFP 80 ± 4, AD-Nup153-GFP 518 ± 14, P < 0.05 ANOVA on RANKS followed by Student-Newman-Keuls Method, n = 5; Fig. 4A). Here, NCAM1 is linked to Alzheimer disease.