Other mature pre- and postsynaptic markers such as synapsin I and PSD95 were analyzed by confocal microscopy and their levels were increased in AD after Nup153 transduction (Fig. 6B-E: SynI puncta: C-GFP 803.75 ± 28.79, AD-GFP 222.36 ± 0.08, AD-Nup153-GFP 836.45 ± 49.64; PSD95 puncta: C-GFP 734.63 ± 43.90, AD-GFP 353.89 ± 24.57, AD-Nup153-GFP 500.13 ± 40.04 P < 0.05 ANOVA followed by SKN test, n = 3). The gene discussed is NUP153; the disease is Alzheimer disease.