NUP153 and Alzheimer disease: However, the presence of Nup153 in AD-NSCs increased proteasomal activity (activity [μM]: WT-NSC-GFP 2.94 ± 0.12; AD-NSC-GFP 1.89 ± 0.01; AD-NSC-GFP-Nup153 2.50 ± 0.136 ANOVA with Bonferroni test P < 0.001, P < 0.05, n = 4–5; Fig. 2C).