ANXA1 has also been found to participate in adaptive immunity against chronic infectious disease [103], by directing the immune response towards a Th1/Th17 response, a response that is associated not only with clearing fungal infection in normothermic mammals, but also the mortality evidenced in susceptible Nearctic populations of M. lucifugus infected by P. destructans [17]. This evidence concerns the gene ANXA1 and fungal infectious disease.