In caerulein (CAE)-induced AP, HPDE6-C7 cells exhibited elevated levels of mitochondrial Ca2+, mitochondrial membrane potential depolarization, mitophagosome formation, and enhanced protein expression of mitophagy markers like the ratio of LC3II/I, PINK1, and PARK, while showing decreased protein expression of p62 and translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) (Lei et al. 2024). This evidence concerns the gene TOMM20 and alkaline phosphatase measurement.