Within our dataset, genes with shifted aging trajectories in psychiatric disease include APLF (in Exc_L2–L3, Exc_L4–L6_1 and Exc_L4–L6_2 neurons), EXPH5 (in Exc_L2–L3 and Exc_L4–L6_3 neurons) and RHBDL3 (in Exc_L4–L6_2 neurons; Fig. 7c–e). Here, EXPH5 is linked to psychiatric disorder.