In the present study, we demonstrated that AAV-pGFAP-CasRx-Ptbp1 crossed the BBB and generated new mCherry/NeuN double-positive neuron-like cells, its origin could be mCherry/GFAP double-positive astrocyte-like glia, in the hippocampus of post-stroke dementia mouse model (Figs. 3a and b, S1, S2). Here, PTBP1 is linked to stroke disorder.