Consistent with the above results, overexpression of IRS4 partly rescued the activation of the PI3K/AKT signaling pathway in PILRB-depleted GC cells (Fig. S6B), demonstrating that IRS4 is a crucial downstream target of PILRB that activates the PI3K/AKT signaling pathway in GC cells. The gene discussed is IRS4; the disease is gastric cancer.