RPS6KB1 and colonic neoplasm: In other primary colon cancer cells (pCan2 and pCan3), the administration of IMT1 (1 μM, 24 h) similarly suppressed the phosphorylation of Akt-S6K1 (Fig. 8H), while demonstrating no impact on the overall expression of total Akt-S6K1 (Fig. 8H).