AKT1 and cancer: Upon treating pCan-1 primary cancer cells with IMT1 (at 1 μM), remarkable suppression of Akt (Ser-473) and ribosomal protein S6 kinase 1 (S6K1, Thr-389) phosphorylation was observed (Fig. 8A), signifying the inhibition of the Akt-mTOR axis.