For OPE exposure alone, according to the data from the NHANES 1999-2008 and 2011-2012, DMTP was significantly associated with higher levels of serum insulin (β = 0.21, 95% CI = 0.06-0.36) and HOMA-IR (β = 0.08, 95% CI = 0.02-0.14) and increased odds of T2DM (OR = 1.05, 95% CI = 1.01–1.08). This evidence concerns the gene INS and type 2 diabetes mellitus.