PPARA and type 2 diabetes mellitus: When exposed to TCPP, the CPT1A gene or PPARA gene is activated, resulting in an enhanced response to xenobiotic stimulus (GO: 0009410), which positively regulates the fatty acid beta-oxidation (GO: 0032000), and further changes in glucose metabolic process (GO: 0006006), which eventually leads to T2DM (Fig. 1D).