Here, we aim to characterize the patterns of MTL neurodegeneration, as measured by antemortem MRI, associated with two proteinopathies that profoundly impact MTL atrophy: phosphorylated tau (p-tau) pathology in AD neuropathological change (ADNC), and phosphorylated TDP-43 (pTDP-43) pathology in LATE neuropathological change (LATE-NC). The gene discussed is MAPT; the disease is nevus comedonicus syndrome.