The RTK-RAS and PI3K-AKT signaling pathways, are known for their oncogenic properties in promoting PCNSL, partly through the induction of abundant cytokines and chemokines.40,41 We observed that alterations in the RTK/Ras and PI3K/AKT pathway components of PCNSL may render tumors more sensitive to SMTR regimen. The gene discussed is AKT1; the disease is primary central nervous system lymphoma.