Interestingly, the exosomal HIF1A-AS2 level was significantly higher in the serum of CRC patients than in normal people, with an area under the receiver operating characteristic (ROC) curve of 0.93, suggesting that exosomal HIF1A-AS2 might take part in the progression of CRC and can function as a diagnostic marker (Fig. 9A, B). The gene discussed is HIF1A; the disease is colorectal carcinoma.