There is therefore a requirement for a mechanism by which to translate across from the frequentist stipulations relating to case-control ORs (as per the current 2015 ACMG/AMP framework) into a Bayesian quantitation of an LR (commensurate with the 2018 SVI framework evolution and forthcoming ACMG framework revision).12 13 Recently, Zanti et al (1) analysed individual-level SNP-array data on 75 657 breast cancer cases and 52 987 controls of European ancestry, (2) calculated age-specific log-relative risk from survival analysis and (3) generated LRs for 24 BRCA1 and 68 BRCA2 variants.20 The gene discussed is BRCA1; the disease is breast carcinoma.