Uniquely enriched pathways for CM-EVs (denoted by #, supplemental figure S9(a)) included the transforming growth factor- β (TGF-β) signaling pathway, associated with targets of miR-20a-5p, miR-145-5p, and miR-424-5p; and prion disease and renal cell carcinoma, associated with miR-148a-3p. The gene discussed is TGFB1; the disease is renal cell carcinoma.