IL17A and liver disorder: Regarding γδT cells, Mdr2−/− mice have been shown to have increased levels of IL-17+ γδT cells in the liver compared with controls.76 Alongside this, i.v. injection with an antibody directed against the γδT-cell receptor reduced fibrosis in Mdr2−/− mice with a corresponding decrease of IL-17 detected in the serum.76 In humans, intrahepatic γδT cells from patients with PSC could produce IL-17 upon stimulation, in contrast to γδT cells from patients with other liver diseases.76 This suggests that γδT cells might be part of the dysregulated Th17 axis in PSC.