However, conditional depletion of KCs (using Clec4fDTR transgenic mice) before cholestasis induction by DDC diet and common bile duct ligation had no effect on disease outcome, thus contesting these cells as major drivers of early pathogenesis.44 Overall, data from mouse models mostly suggest a causative role of these cells in driving fibrosis development in the context of cholestasis, although considerable differences exist in the composition of the mononuclear phagocyte system across species. Here, TBCE is linked to cholestasis.