CASP3 and acute myeloid leukemia: Tsang et al. first reported in 2008 that let-7a can affect drug-induced apoptosis of A431 cells and HepG2 cells through Caspase-3; Fasihi-Ramandi et al. found in 2018 that let-7a-5p could block Caspase-3 to induce apoptosis of HL60 cells and inhibit the proliferation of AML [37].